Trent Edwards went 25-of-30 for 261 yards and a touchdown, and Kawika Mitchell intercepted a pass from Philip Rivers at the goal line to thwart a potential go-ahead score as the Bills beat the Chargers, 23-14.
Mitchell's interception allowed Edwards to engineer a seven-play, 43-yard drive to set up Rian Lindell's 44-yard field goal with 3:17 remaining. Then Mitchell came through again, when he forced Rivers to fumble on San Diego's next possession.
Edwards hit Lee Evans on a 2-yard touchdown pass and Marshawn Lynch also scored for the AFC East-leading Bills, off to their first 5-1 start since 1995. Buffalo got the 200th home win in franchise history.
Titans 34, Chiefs 10 - LenDale White rushed for three touchdowns and 149 yards, including an 80-yard sprint, and Chris Johnson broke free for a 66-yard gallop while rushing for 168 yards.
Steelers 38, Bengals 10 - Mewelde Moore got into the end zone three times. The Steelers defense got to the quarterback seven times.
Giants 29, 49ers 17 - Brandon Jacobs ran for two touchdowns, Eli Manning threw for one, Michael Johnson had two interceptions and the Giants managed to make fewer mistakes than the woeful 49ers.
Ravens 27, Dolphins 13 - Cam Cameron, the Baltimore Ravens' offensive coordinator, orchestrated four scoring drives against the team he coached to only one win last year. Joe Flacco threw for 232 yards and a touchdown.
Bears 48, Vikings 41 - Kyle Orton threw two touchdown passes and special teams chipped in with two more.
Texans 28, Lions 21 - Owen Daniels scored two touchdowns and rookie Steve Slaton and Ahman Green added a touchdown each. Andre Johnson had 11 receptions for 141 yards for his third straight 100-yard game.
Redskins 14, Browns 11 - Clinton Portis really started piling up the yards. Santana Moss starting doing spin moves after catching the ball. London Fletcher led a huge goal line stand. The Browns, not to be outdone, made things interesting with a late touchdown, a 2-point conversion, and a field-goal attempt that was wide right with 25 seconds to play.
After nearly putting the fans to sleep, two teams packed a lot into a little bit of time Sunday.
Bucs 20, Seahawks 10 - Jeff Garcia threw a 47-yard touchdown pass to Antonio Bryant on Tampa Bay's first drive and Earnest Graham added a 1-yard TD run.
